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http://www.sudoc.fr/195046056 |
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20240829055200.0 |
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|a Interferon gamma improves long-term efficacy of allogeneic mesenchymal stem cell therapy after acute myocardial infarction
|f Pierre Teruin
|g sous la direction de Guillaume Lamirault
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|a [Lieu de publication inconnu]
|c [éditeur inconnu]
|d 2016
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| 230 |
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|a Données textuelles
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|a Bibliogr. 50 réf.
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|a La thèse papier est la seule version officielle
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|z Reproduction de
|b Thèse d'exercice
|c Médecine. Cardiologie et maladies vasculairesAnesthésie-Réanimation
|e Nantes
|d 2016
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| 330 |
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|a Cardiac cell therapy using allogeneic mesenchymal stem cells (MSCs) loses efficacy on the long term, probably by immune rejection of the cells. Our working hypothesis is that pretreatment with IFN-g of allogeneic MSCs improve cardiac cell therapy. In a rat model of allogeneic MSCs injection in post myocardial infarction, we compare the effect of autologous or allogeneic MSCs, pretreated or not with IFN-g. Cardiac function was assessed by echocardiography, alloimmunization by blood tests and cardiac repair by histological study. Despite a humoral and cellular alloimmunization, allogeneic MSCs pretreated with IFN-g improve cardiac repair and cardiac function in the long-term, similarly to autologous MSCs. Our study shows a beneficial effect of IFN-g specific to the context of allogeneic cell therapy and suggests a favorable immune modulation induced by IFN-g as the mechanism of the effect.
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|a Un logiciel capable de lire un fichier au format PDF
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|0 195045823
|t Interferon gamma improves long-term efficacy of allogeneic mesenchymal stem cell therapy after acute myocardial infarction
|f Pierre Teruin
|c [Lieu de publication inconnu]
|n [éditeur inconnu]
|d 2016
|p 1 vol. (47 f.)
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|a Interférons gamma
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| 606 |
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|a Thérapeutique cellulaire
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| 606 |
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|a Isoimmunisation
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|a Université de Nantes
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|a Nantes Université
|b Pôle Santé
|b UFR Médecine et Techniques Médicales
|c Nantes
|4 295
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